"Our approach also provides rapid information on which cell types are present and whether their number has changed in comparison to the other cells in the blood," explains Otto. Our main research focuses on understanding the mechanical properties of molecules, cells and tissue and their impact on biological function in the area of cardiovascular physiology and pathology. : ++49 3834 86 22342 Fax: ++49 3834 86 22341 oliver.otto @ uni-Greifswald.de. Microfluidics by soft lithography has proven to be of key importance for biophysics and life science research. This new, label-free, method offers researchers the great advantage that they can simply analyze a sample and interpret the data to find out what is there, without a starting point, and dRT-DC does not alter the cells themselves. Guzniczak E, Otto O, Whyte G, Willoughby N, Jimenez M, Bridle H, Lab Chip. He is interested in muscle mechanobiology so he feels right at home here with us. Under existing technology, researchers must already know what they are looking for, using matched ‘labels’ and fluorescent dyes for the cell they want to find. Our results reveal that the stiffness of a single cell exceeds the one of tissue by a factor of 10 thus implying that tissue mechanics is governed to a significant extent by cell-cell interaction. Aside from the occasional cake, Astrid is also our gateway to an endless supply of fresh eggs, pumpkins, plums and all sorts of vegetables, fruits and flowers she brings from her garden .
2019 Jan 24;10(1):415. Three years ago, Dr. Oliver Otto from the University of Greifswald and scientists from the TU Dresden developed a technique called real-time deformability cytometry (RT-DC) to measure the mechanical properties of cells. In the evenings you might spot Ricardo trying to train his cat to guard his house (progress report anxiously awaited). Purifying stem cell-derived red blood cells: a high-throughput label-free downstream processing strategy based on microfluidic spiral inertial separation and membrane filtration. From the mechanical properties, the scientists can also determine whether immune cells are activated or not. 2020 Feb 26. https://doi.org/10.1002/bit.27319 Online ahead of print. When we test how soft a mattress is, or squeeze a pear to find out whether it is ripe, we are assessing something’s mechanical properties. : 030 3465 529 02, presse@dzhk.de, Dr. Oliver Otto, Center for Innovation Competence HIKE Humoral Immune Reactions in Cardiovascular Diseases, University of Greifswald, oliver.otto@uni-greifswald.de. "Previously, this was only possible by using fluorescence-labelled antibodies or complex computer programs," explains DZHK scientist Dr. Otto, who heads the biomechanics research group at the University of Greifswald.
Scientists at the German Centre for Cardiovascular Research (DZHK), the University of Greifswald and the TU Dresden have developed a new way to identify different types of immune cells, without using the standard, complex process known as ‘labelling’. Contact:
"Based on these results in combination with the mechanical properties of the cells, further targeted investigations can then be carried out, for example on the molecular changes.”. Doreen is our biology laboratory technician. It is sad to see our colleagues go, but that's how life flows, isn't it? He never misses a chance to travel together with friends and is always ready to join on a good laugh. With the new dynamic RT-DC (dRT-DC), it is even possible to distinguish between certain subtypes of immune cells, the B and T lymphocytes. 2019 Jan 24;10(1):415. With the new dynamic RT-DC (dRT-DC), it is even possible to distinguish between certain subtypes of immune cells, the B and T lymphocytes. The scientists from Greifswald regard their method as complementary to previous tools. "The ability of the dRT-DC to identify and characterize cells in a cell mixture might be relevant for a better understanding of the role of the immune system in acute and chronic diseases," said Professor Stephan Felix, Director of the Clinic and Polyclinic for Internal Medicine at the University Hospital of Freiburg. In his spare time he likes pumping his bicycle, and running 10K just because he can. Ricardo is a microbiologist trained in biochemistry, who developed a passion for biological mechanics ever since he begun stretching proteins - and now he leveled up to cells! Philos Trans R Soc Lond B Biol Sci. She is the commander-in-chief of the daily running of our labs and without whom our lives would be a chaos. Beware, he is super friendly and likes cookies. So far, however, this has only been able to measure how elastic the cells are. Pires RH, Shree N, Manu E, Guzniczak E, Otto O, Philos Trans R Soc Lond B Biol Sci. Bob Fregin, a PhD student in Dr. Otto's research group, has improved the method by increasing the number of images taken of each cell. Cells are labelled with a fluorescence-labelled antibody that recognizes a structure on their surface but this ‘fluorescence-labelling’ can alter the properties and function of the cells. Guck Division. Here the authors create virtual fluidic channels inside the cuvette of commercial flow cytometers to dynamically tune channel cross section to When we test how soft a mattress is, or squeeze a pear to find out whether it is ripe, we are assessing something’s mechanical properties. With a pair of pipettes she is faster to pull the trigger than any wild west bandit - and when she enters the lab, we all know she is coming to collect the reward! Dr. Oliver Otto is our supreme leader and co-inventor of the RT-DC technique. In his spare time he likes pumping his bicycle, and running 10K just because he can. The first promising results have already been obtained from ongoing projects. University of New South Wales, Sydney. Christine Vollgraf, Press and Public Relations, German Centre for Cardiovascular Research (DZHK), Tel.
University of Greifswald ZIK HIKE Centre for Innovation Competence - Humoral Immune Reactions in Cardiovascular Diseases Biomechanics Fleischmannstraße 42-44 17489 Greifswald Germany Tel. The scientists from Greifswald regard their method as complementary to previous tools. This is of high importance in areas where molecular or biochemical labels are not available or not wanted, e.g.
The method can identify cells based on their mechanical properties, within a few seconds and in just one drop of blood. It has also been known for some years that these mechanical properties can distinguish cells from each other.
Three years ago, Dr. Oliver Otto from the University of Greifswald and scientists from the TU Dresden developed a technique called real-time deformability cytometry (RT-DC) to measure the mechanical properties of cells.
When he is not recovering from volleyball injuries, he is volunteering in organizing the cultural activities of the Greifswald shipyard museum. High-throughput rheological measurements of cells and cell clusters by microfluidics is limited by fixed channel dimensions.
Deformability-induced lift force in spiral microchannels for cell separation. External link.
When not exploring ideas in the lab, we might find him reading by the sea. So far, however, this has only been able to measure how elastic the cells are. Three years ago, Dr. Oliver Otto from the University of Greifswald and scientists from the TU Dresden developed a technique called real-time deformability cytometry (RT-DC) to measure the mechanical properties of cells. Fregin B, Czerwinski F, Biedenweg D, Girardo S, Gross S, Aurich K, Otto O. Nat. This Analysis compares microfluidics-based methods for assessing mechanical properties of cells in high throughput.
Loop enables you to stay up-to-date with the latest discoveries and news, connect with researchers and form new collaborations. Oliver OTTO, Research group leader of University of Greifswald, Greifswald | Read 118 publications | Contact Oliver OTTO Cells are labelled with a fluorescence-labelled antibody that recognizes a structure on their surface but this ‘fluorescence-labelling’ can alter the properties and function of the cells. M. Mokbel, D. Mokbel, A. Mietke, N. Träber, S. Girardo, "High-throughput Cell and Spheroid Mechanics in Virtual Fluidic Channels" In this work by Panhwar, Czerwinski, High-throughput rheological measurements of cells and cell clusters by microfluidics is limited by fixed channel dimensions. Katharina Gaus, Scientia Professor and Head, EMBL Australia Node in Single Molecule Science. Cardiomyocyte Mechanodynamics Under Conditions of Actin Remodelling. This is the little corner where we remember them. Now, for the first time it is possible to distinguish between certain cells of the immune system, the B- and T-lymphocytes, without having to use a fluorescence-labelled antibody.
From the mechanical properties, the scientists can also determine whether immune cells are activated or not. Some think he is half man, half machine. He is a great cook, baker, and has unusual powers of fixing broken things. enable rheological measurements from cells and cell clusters. Scientists at the German Centre for Cardiovascular Research (DZHK), the University of Greifswald and the TU Dresden have developed a new way to identify different types of immune cells, without using the standard, complex process known as ‘labelling’.
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